GI Therapies
 
 

Gastromotility Disorders

 

The symptoms from gastrointestinal motility disorders are common and can range from slight discomfort and inconvenience to outcomes with serious medical consequences.

GI Therapies is focussing on those disorders that give rise to chronic constipation that are primarily a result of poor motility in the lower bowel.


1. Chronic constipation

Constipation is a common symptom in children and adults, males and females and across most ethnic groups1. In many cases, the problem is transient and well managed with laxatives, osmotic agents, bulking agents, behavioural therapy and other related first line therapies. Nevertheless, in some patients these agents and approaches are not sufficient and the condition remains chronic and unresolved, often for many years. For these patients, there is a significant impact on their quality of life and economic burden2,3. In some cases, surgery and other more invasive interventional procedures are required.

In addition to causes that are unknown, constipation is also associated with the use of medications such as analgesics, antihypertensive and antiparkinsonian drugs, medical conditions such as various metabolic diseases and mechanical obstruction. The American Gastroenterological Association Technical Review on Constipation4  summarises current thinking around the diagnosis and treatment of this pervasive condition.

  1. Cook et al (2009), Neurogastroenterology Motil , 21 (Suppl. 2), 1-8
  2. Dennison et al (2005), Pharmacoeconom,  23 (5), 461-476
  3. Belsey, (2010), Alimentary Pharmacol. & Therapeutics, 31, 938-949
  4. Gastroenterology, (2013), 144 (1), 218-238


2. Irritable bowel syndrome

Irritable bowel syndrome (IBS) is a functional bowel disorder in which abdominal pain or discomfort is associated with defecation and/or a change in bowel habit. Sensations of discomfort (bloating), distension and disordered defecation are commonly associated features.

3. Gastroparesis

Gastroparesis is a syndrome characterised by delayed gastric emptying in absence of mechanical obstruction of the stomach. The cardinal symptoms include postprandial fullness (early satiety), nausea, vomiting, and bloating. In the more severe cases, chronic constipation can arise as a consequence of the disorder.